Genotype harmonizer: automatic strand alignment and format conversion for genotype data integration

Fetal Vegf Genotype is More Important for Abortion Risk than Mother Genotype

Background VEGF gene has been reported to be related with many diseases and recurrent pregnancy loss in various studies. VEGF polymorphisms are risk factors for pregnancy losses, and generally studies report only women’s genetic analyses. To evaluate the association between VEGF A C405G, C460T, C936T and C2578A polymorphisms and spontaneous abortion, we studied the genotypes of spontaneously a...

An optimal algorithm for automatic genotype elimination.

In an effort to accelerate likelihood computations on pedigrees, Lange and Goradia defined a genotype-elimination algorithm that aims to identify those genotypes that need not be considered during the likelihood computation. For pedigrees without loops, they showed that their algorithm was optimal, in the sense that it identified all genotypes that lead to a Mendelian inconsistency. Their algor...

Semi-automatic Ontology Alignment for Geospatial Data Integration

In geospatial applications with heterogeneous databases, an ontology-driven approach to data integration relies on the alignment of the concepts of a central ontology that describe the domain, with the concepts of the ontologies that describe the data in the local databases. Once the alignment between the global ontology and each local ontology is established, users can potentially query hundre...

Cleaning genotype data.

The identification of genes contributing to variation in complex phenotypes requires genetic data of high fidelity. Thus, the identification of pedigree and genotyping errors is a crucial prerequisite to the analysis of data from a genome scan for disease genes. The problem has been given little attention in most gene hunting papers; the focus has often been on eliminating mendelian inconsisten...

“Goo STATISTICAL METHODS FOR GENOTYPE ASSAY DATA